Dramatic advances in gene sequencing technology are enabling scientists to conduct studies of organisms that once cost millions of dollars — billions, for the human genome — for only thousands of dollars today. Watch C. Thomas Caskey, M.D., the scientist who helped prove the universality of genes across organisms and who discovered the principal of anticipation — how some genetic diseases get worse in each succeeding generation — during the keynote address during Florida Genetics 2010. He talks about next generation genome sequencing, gives a unique historical perspective of quantum advances that have taken place in biology, and talks about his current work to use sequencing to understand schizophrenia. Introduction by Kenneth Berns, M.D., Ph.D., director of the UF Genetics Institute.